Ethylenediaminetetraacetic Acid （EDTA ACID）60-00-4
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Ethylenediaminetetraacetic acid (EDTA), also called EDTA acid, is an aminopolycarboxylic acid with the formula [CH2N(CH2CO2H)2]2. This white, slightly water-soluble solid is widely used to bind to iron (Fe2+/Fe3+) and calcium ions (Ca2+), forming water-soluble complexes even at neutral pH. It is thus used to dissolve Fe- and Ca-containing scale as well as to deliver iron ions under conditions where its oxides are insoluble. EDTA is available as several salts, notably disodium EDTA, sodium calcium edetate, and tetrasodium EDTA, but these all function similarly.
Diethylene Triamine Penta Acetic Acid(DTPA ACID)67-43-6
The molecule can be viewed as an expanded version of EDTA and is used similarly.
Tetrasodium edta (EDTA 4NA) is one of the chelating agent which can be used as the stabilizer of cosmetics.
EDTA CA is applied as trace elements in agriculture, and as coloring agent and food additive in food industry.
EDTA ZN is a white crystalline powder and soluble in water, zinc stay in chelated form.
EEDTA MN is a kind of stable water-soluble metal chelate, manganese existed in a chelated state.
Nitrilotriacetic Acid(NTA ACID)139-13-9
Nitrilotriacetic acid (NTA ACID) is the aminopolycarboxylic acid with the formula N(CH2CO2H)3.
Uses Of Ethylenediaminetetraacetic Acid (EDTA ACID)
Lead poisoning and heavy metal toxicity
Chelation therapy using Ethylenediaminetetraacetic Acid (EDTA ACID) is the medically-accepted treatment for lead poisoning. Injected intravenously and once in the bloodstream, Ethylenediaminetetraacetic Acid (EDTA ACID) traps lead and other metals, forming a compound that the body can eliminate in the urine. The process generally takes 1 to 3 hours. Other heavy metal poisonings treated with chelation include mercury, arsenic, aluminum, chromium, cobalt, manganese, nickel, selenium, zinc, tin, and thallium. Chelating agents other than Ethylenediaminetetraacetic Acid (EDTA ACID)are also used to clear several of these substances from the bloodstream.
Heavy metal toxicity in humans has been associated with many health conditions, including heart disease, attention deficit/hyperactivity disorder (ADHD), Alzheimer disease, immune system disorders, gastrointestinal disorders (including irritable bowel syndrome, or IBS), and autism.
Digoxin toxicity
Ethylenediaminetetraacetic Acid (EDTA ACID) has also been used to treat digoxin toxicity, although most doctors prefer to use other methods. In this case, Ethylenediaminetetraacetic Acid (EDTA ACID) helps remove excess levels of digoxin, a medication that is used to treat abnormal rhythms of the heart.
Atherosclerosis
Evidence that Ethylenediaminetetraacetic Acid (EDTA ACID) chelation therapy is effective for heart disease is mixed. Proponents believe it may help people with atherosclerosis (hardening of the arteries) or peripheral vascular disease (decreased blood flow to the legs) by clearing clogged arteries and improving blood flow. However, the few studies that show it may help have been poorly designed, making the results questionable.
The theory that Ethylenediaminetetraacetic Acid (EDTA ACID) clears clogged arteries and improves blood flow is based on an outdated model about what causes heart disease. Newer theories include the possibility that Ethylenediaminetetraacetic Acid (EDTA ACID) functions like an antioxidant, preventing damaging molecules known as free radicals from injuring blood vessel walls and allowing plaque to build up. In fact, studies suggest that Ethylenediaminetetraacetic Acid (EDTA ACID) chelation therapy in combination with oral high-dose vitamins and minerals significantly reduced the occurrence of cardiac events compared to placebo. Other studies suggest Ethylenediaminetetraacetic Acid (EDTA ACID) chelation reduces further cardiac events among people who have diabetes, who have already had a heart attack.
Dentistry
Ethylenediaminetetraacetic Acid (EDTA ACID) is used in dentistry as a chelating agent for smear layer removal from root canal walls.
The Mechanism of Action of Ethylenediaminetetraacetic Acid (EDTA ACID)
Chelation agents function by forming bonds with various metal ions, including calcium, zinc, lead, etc. After these bonds are formed, a soluble chelate-metal complex is created that can be excreted from the body. In a similar method, Ethylenediaminetetraacetic Acid (EDTA ACID) has a complex structure that allows it to bind various metals. The molecular composition of Ethylenediaminetetraacetic Acid (EDTA ACID) consists of multiple oxygen molecules, which function to donate electrons and form coordination complexes with metal ions. When calcium disodium edetate binds to metals, the calcium is displaced from the structure. The bonds formed with the metals are extremely strong and prevent further toxic effects from occurring before excretion out of the body.
● Absorption
Ethylenediaminetetraacetic Acid (EDTA ACID) is rapidly absorbed through intravenous access and moves into the plasma and interstitial fluids. Oral administration is avoided due to very low (less than 5%) absorption and elevated lead concentrations within the gastrointestinal tract.
● Distribution
Ethylenediaminetetraacetic Acid (EDTA ACID) is distributed throughout the entire extracellular compartment. Within the blood, the molecule stays within the plasma. It has an ionic form preventing it from entering into cells.
● Metabolism/Excretion
After IV administration, calcium Ethylenediaminetetraacetic Acid (EDTA ACID) largely goes unmetabolized and is excreted in its administered form through the kidneys. Similarly, the chelate-metal complexes will be quickly excreted in the urine. The half-life is around 20 to 60 minutes. The kidneys can filter out the drug and secrete it into the tubular lumen.
In coordination chemistry, EDTA4− is a member of the aminopolycarboxylic acid family of ligands. EDTA4− usually binds to a metal cation through its two amines and four carboxylates, i.e., it is a hexadentate ("six-toothed") chelating agent. Many of the resulting coordination compounds adopt octahedral geometry. Although of little consequence for its applications, these octahedral complexes are chiral. The cobalt(III) anion [Co(EDTA)]− has been resolved into enantiomers.
Many complexes of EDTA4− adopt more complex structures due to either the formation of an additional bond to water, i.e. seven-coordinate complexes, or the displacement of one carboxylate arm by water. The iron(III) complex of Ethylenediaminetetraacetic Acid (EDTA ACID) is seven-coordinate. Ethylenediaminetetraacetic Acid (EDTA ACID) forms especially strong complexes with Mn(II), Cu(II), Fe(III), Pb(II) and Co(III).
Several features of EDTA's complexes are relevant to its applications. First, because of its high denticity, this ligand has a high affinity for metal cations:
[Fe(H2O)6]3+ + H4EDTA ⇌ [Fe(EDTA)]− + 6 H2O + 4 H+ Keq = 1025.1
The equilibrium quotient shows that metal ions compete with protons for binding to Ethylenediaminetetraacetic Acid (EDTA ACID). Because metal ions are extensively enveloped by EDTA, their catalytic properties are often suppressed. Finally, since complexes of EDTA4− are anionic, they tend to be highly soluble in water. For this reason, Ethylenediaminetetraacetic Acid (EDTA ACID)is able to dissolve deposits of metal oxides and carbonates.
The pKa values of free Ethylenediaminetetraacetic Acid (EDTA ACID) are 0, 1.5, 2, 2.66 (deprotonation of the four carboxyl groups) and 6.16, 10.24 (deprotonation of the two amino groups).
Why Do People Take Ethylenediaminetetraacetic Acid (EDTA ACID)
Ethylenediaminetetraacetic Acid (EDTA ACID) is sometimes prescribed by doctors to clean toxic metals, such as lead, from the blood. Doctors have used the molecule for decades to treat heavy metal poisoning. In those cases, it is given through an IV.
Ethylenediaminetetraacetic Acid (EDTA ACID) is also an ingredient in some prescription cancer-fighting medicines.
Preliminary studies show that intravenous EDTA therapy under physician supervision may help patients who have had a heart attack, particularly if they have diabetes.
Some people take EDTA to try to treat:
● Diabetes
● Peripheral vascular disease
● Alzheimer's disease
What Is the Process of Making Ethylenediaminetetraacetic Acid (EDTA ACID)
The process includes the following steps:
Mixing ethylene diamine and sodium hydroxide and heating, dropping hydroxyl acetonitrile within 5 hr, reaction after finishing dropping for at least 30 min until releasing ammonia completely.
Adding EDTA to regulate pH value to 5-6.
Adding active carbon into the reacted liquid to decolorize.
Adding EDTA to regulate pH value to 3.5-4.5.
Concentrating the reacted liquid to crystallize, separating and drying to obtain EDTA disodium salt product.
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HANGZHOU BETTER CHEMTECH LTD is a comprehensive chemical company specializing in Chemical Production, Management, Application Development and Brand Promotion. Our headquarters is in Hangzhou, China, with service centers in Mumbai, India, and we also have cooperative production bases in China and India.
China's chemical industries are large in scale, but fall short in terms of technical knowhow. In the face of increasingly stringent requirements of the state and the people for the environment and safety production in China, chemical industries are facing large-scale supply shortages. The global chemical supply chain is facing severe challenges in many subdivisions. The chemical industry workforce has lost confidence in the future development of the industry, but BETTER believes that the reconstruction of chemical supply and value chain can lead to the overall development of the industry and the workforce.
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